Roman Popat


Roman has joined the Centre in 2011.

Research details:

Far from autonomous, bacterial cells communicate with their biotic neighbours by producing and detecting small diffusible molecules which have a profound effect on their behaviour and pathogenesis. The molecular and genetic underpinnings of bacterial communication are well described but the function of such communicative traits remains elusive. Are small diffusible molecules used to monitor population density (Quorum Sensing) or feedback information about the abiotic environment? What stops cells from producing more or less of the communicative molecules to manipulate the behaviour of their neighbours? In addition there is a growing interest in targeting bacterial communication to disrupt the virulence of pathogens without killing them outright. Are such approaches immune to the evolution of resistance as has been claimed? We aim to understand these questions by combining empirical and theoretical approaches.

The Brown Group

Roman Popat's Website